葉信顯
姓名 葉信顯
電子郵件
聯絡電話 +886-2-28267000 ext.67383
EDUCATION/TRAINING 英國曼徹斯特大學生物醫學與健康學院沃福森影像中心與美國德州大學安德森癌症中心實驗影像系 雙邊學程醫學博士
個人連結1 https://skyeyeh.wordpress.com
職稱 國立陽明交通大學 腦科學中心 副研究員
研究專長 Molecular imaging, Nuroimaging, Translational Radiopharmaceutical Sciences
自傳
 

研究興趣

分子癌症影像、腦神經影像、影像導引式治療藥物篩選、多重影像模組藥物動力學、放射藥物研發之轉譯醫學
研究內容為利用新興正子造影劑評估其在癌症與神經系統疾病的適用性。所應用的影像評估系統包括幾個核心技術，如細胞攝取，細胞結合試驗，動物組織萃取，數位式放射顯影法，動態藥物藥效學與多重影像擷取與比較(PET, SPECT,Optical image,CT and MRI)。本研究團隊將高階影像技術與分析方法應用於數種癌症動物模式或神經退化性疾病之基因鼠;藉此開發新型影像診斷造影劑或是應用活體影像高效率篩選開發中或老藥新用之治療藥物成效。
 

Current activity

  • Neurodegenerative disease: Alzheimer's disease (AD) and Huntington’s Disease (HD)
  • Psychiatric disease: Post-traumatic stress disorder (PTSD)
  • Oncology: non small cell carcinoma lung cancer
年度 論文名稱
2022 Skye Hsin-Hsien Yeh, Chi-Jung Tsai, Tsung-Hsun Yu, Younn-Hsiau Chian, Shinn-Zong Lin, Nan-Jing Peng, Wen-Sheng Huang*. Tc-99m-TRODAT-1 SPECT Revealed Significantly Decreased Striatal Dopamine Transport Availability in Late Mid-Aged Healthy Taiwanese and then Remained Stable. Clinical Nuclear Medicine, Vol.47, No.3 March 2022. (IF:10.782, Ranking:6/136, 4.4%) , 2022
2022 Skye Hsin-Hsien Yeh, Yu-Yeh Kuo, Wen-Sheng Huang, Chuang-Hsin Chiu, Tsung-Hsun Yu, Leo Garcia Flores II, Chi-Jung Tsai, Cheng-Yi Cheng and Kuo-Hsing Ma. Preliminary Results on the Long-Term Effects of Dextromethorphan on MDMA-Mediated Serotonergic Deficiency and Volumetric Changes in Primates Based on 4-[18F]-ADAM PET/MRI. Front. Neurosci., 19 May 2022 https://doi.org/10.3389/fnins.2022.837194. (IF:5.512, Ranking:87/274, 31.86%), 2022
2022 Yu-Ling Gan, Chen-Yu Wang, Rong-Heng He, Pei-Chien Hsu , Hsin-Hsien Yeh , Tsung-Han Hsieh, Hui-Ching Lin, Ming-Yen Cheng, Chung-Jiuan Jeng, Ming-Chyi Huang Yi-Hsuan Lee. FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus. J Neuroinflammation. 2022 Jun 15;19(1):152. doi: 10.1186/s12974-022-02517-8. (IF:9.954, Ranking:24/224, 8.8%), 2022
2022 Chi-Jung Tsai, Chuang-Hsin Chiu, Yu-Yeh Kuo, Wen-Sheng Huang, Tsung- Hsun Yu, Leo Garcia Flores II, Skye Hsin-Hsien Yeh* and Kuo-Hsing Ma*. (2022, Jun). Amitriptyline Accelerates SERT Binding Recovery in a Rat 3,4- Methylenedioxymethamphetamine (MDMA) Model: In Vivo 4-[18F]-ADAM PET Imaging. Int. J. Mol. Sci. 2022, 23(13), 7035. (IF:6.208, Ranking:76/224, 33.9%) , 2022
2022 Chuang-Hsin Chiu, Shao-Ju Weng, Skye Hsin-Hsien Yeh, Yun-Ting Jhao, Hsien-Feng Chang, Wen-Sheng Huang,Cheng-Yi Cheng, Chun-Chang Yeh, Kuo-Hsing Ma. Assessment of the anti-nociceptive effects of fetal ventral mesencephalic tissue allografts in a rat model of hemi-Parkinson’s disease using fMRI. Front. Aging Neurosci. https://doi.org/10.3389/fnagi.2022.948848, 2022
2022 Skye Hsin-Hsien Yeh, Chuang-Hsin Chiu, Hung-Wen Kao, Ching-Po Lin, Yu-Hus Lai, Wen-Sheng Huang. Multi-Modal Synergistic 99mTc-TRODAT-1 SPECT and MRI for Evaluation of the Efficacy of Hyperbaric Oxygen Therapy in CO-Induced Delayed Parkinsonian and Non-Parkinsonian Syndromes. Antioxidants 2022, 11(11), 2289; https://doi.org/10.3390/antiox11112289. (IF:7.675, 4/63=6.3%), 2022
2021 Wen-Tsung Ho, Tsung-Hsun Yu, Wen-Hung Chao, Bao-Yen Wang, Yu-Yeh Kuo, Skye Hsin-Hsien Yeh*. Elevation Hydrogen/Oxygen generating patch of increase blood hydrogen and oxygen level. Appl. Sci. 2021, 11(24), 11680; https://doi.org/10.3390/app112411680. (IF:2.838, Ranking:39/92, 52.2%) , 2021
2021 Skye Hsin-Hsien Yeh, Feng-Shiun Shie, Hui-Kang Liu, Heng-Hsiang Yao, Pei-Chen Kao, Yi-Heng Lee, Li-Min Chen, Shu-Meng Hsu, Li-Jung Chao, Kuan-Wei Wug, Young-Ji Shia, Huey-Jen Tsay. A high sucrose diet aggravates Alzheimer's disease pathology, attenuates hypothalamic leptin signaling, and impairs food-anticipatory activity in APPswe/PS1dE9 mice. Neurobiology of Aging 2019 Nov DOI: 10.1016/ j.neurobio laging.2019.11.018. (IF:4.673, Ranking:14/53, 26.42%) , 2021
2021 Chi-Wei Chang, Chuang-Hsin Chiu , Ming-Hsien Lin , Hung-Ming Wu, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Ya-Yao Huang, Chyng-Yann Shiue, Wen-Sheng Huang , Skye Hsin-Hsien Yeh*. GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression. EJNMMI Res. 2021 Mar 16;11(1):26. doi: 10.1186/s13550-021-00768-9. (IF:3.138, Ranking:59/134, 44.03%) , 2021
2021 Skye Hsin-Hsien Yeh, Ming Hsien Lin, I I Leo Garcia Flores , Uday Mukhopadhyay , Danial Young , Kazuma Ogawa, Jeong-Hwan Jeong, William Tong, Juri G Gelovani , Nobuyoshi Fukumitsu*. In Vivo Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [18F]FAHA and [18F]FDG PET/CT Imaging. Molecular Imaging, 2021 Mar 31;2021:6660358. doi: 10.1155/2021/6660358. eCollection 2021. (IF:4.488, Ranking:29/134, 21.64%) , 2021
2021 Skye Hsin-Hsien Yeh*, Wei-Chung Chang, Shu-Meng Hsu, Ming Hsien Lin, Min-Ching Chung, Chi-Shiang Ke, Yen-Chun Lee, Chorng-Jer Hwang, David J. Yang. Chelation-tamoxifen conjugates for imaging of estrogen receptors. Cancer Biotherapy and Radiopharmaceuticals, 2021, doi: 10.1089/cbr.2021.0169. (IF:3.099, Ranking:60/134, 44.78%) , Cancer Biotherapy and Radiopharmaceuticals, 2021
2021 Skye Hsin-Hsien Yeh, Wen-Sheng Huang, Chuang-Hsin Chiu, Chuan-Lin Chen, Hui-Ting Chen, Dae Yoon Chi, Zhengxing Ge, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Chun-Tse Hung, Geng-Ying Li, Chi-Wei Chang*. Automated synthesis and initial evaluation of (4'-amino-5',8'-difluoro-1'H-spiro[piperidine-4,2'-quinazolin]-1-yl)(4-[18F]fluorophenyl)methanone for PET/MR imaging of inducible nitric oxide synthase. Molecular Imaging, 2021 July, doi: 10.1155/2021/9996125. eCollection 2021. (IF:4.488, Ranking:29/134, 21.64%) , Molecular Imaging, 2021
2019 Wen-Sheng Huang, Guann-Juh Chen, Tung-Han Tsai, Chen-Yi Cheng, Chyng-Yann Shiue, Kuo-Hsing Ma, Skye Hsin-Hsien Yeh*. In vivo long lasting alterations of central serotonin transporter activity and associated dopamine synthesis after acute repeated administration of methamphetamine. EJNMMI Res. 2019 Sep18;9(1):92. doi: 10.1186/s13550-019-0557-y. (IF:3.138, Ranking:59/134, 44.03%) , 2019
2018 Nobuyoshi Fukumitsu, Skye Hsin-Hsien Yeh*, Leo Garcia Flores II, Uday Mukhopadhyay, Daniel Young, Kazuma Ogawa, Hwan-Jeong Jeong, William Tong, and Juri G. Gelovani. In Vivo 6-([18F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity. Contrast Media & Molecular Imaging, Volume 2018 (2018), https://doi.org/10.1155 /2018/3612027. (IF:3.161, Ranking:58/134, 43.28%) , 2018
2018 Yi-Heng Lee, Hao-Chieh Hsu, Pei-Chen Kao, Young-Ji Shiao, Skye Hsin-Hsien Yeh, Feng-Shiun Shie, Shu-Meng Hsu, Chih-Wen Yeh, Hui-Kang Liu, Shi-Bing Yang, Huey-Jen Tsay. Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/ PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation. Int J Mol Sci. 2018 Aug 8;19(8). pii: E2333. doi: 10.3390/ijms19082333. (IF:5.923, Ranking:67/298, 22.48%), 2018
2018 Paulo Henrique Rosado-De-Castro*, David Yang, Hwan-Jeong Jeong, Kazuma Ogawa, Marcos Fabio Henriques DosSantos, Skye Hsin-Hsien Yeh#. Emergent Techniques for Transporter and Receptor-Based Imaging and Interventional Molecular Imaging. Editorial article, Contrast Media & Molecular Imaging, Volume 2018 |Article ID 7615308 | https://doi.org/10.1155/2018/7615308. (IF:3.161, Ranking:58/134, 43.28%), 2018
2015 Chi-Wen Yeh, Skye Hsin-Hsien Yeh, Feng-Shiun Shie, Wen-Sung Lai, Hui-Kang Liu, Tsai-Teng Tzeng, Huey-Jen Tsay and Young-Ji Shiao. Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice. Neurobiol Aging. 2015 Jul 18. pii: S0197-4580(15)00382-6. (IF:5.013 ,Ranking:16%)., 2015
2015 Bonomi R, Mukhopadhyay U, Shavrin A, Yeh HH, Majhi A, Dewage SW, Najjar A, Lu X, Cisneros GA, Tong WP, Alauddin MM, Liu RS, Mangner TJ, Turkman N, Gelovani JG. Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain. PLoS One. 2015 Aug 5;10(8):e0133512. (IF:3.53, R=8/56=14%), 2015
2015 Hui-Ching Lin, Cheng-Ta Li, David Tat-Wei Tan, Chi-Wei Cheng, Ta-Kai Chou, Fan-Lin Kong, Tsung-Hsun Yu, Wen-Sheng Huang, Dong-Ping Su, Ren-Shyan Liu, Skye Hsin-Hsien Yeh*. Non-linear alteration of serotonin transport availability in posttraumatic stress disorder measured with 4-[18F]ADAM positron emission tomography. Current Molecular Imaging. 2015 Nov. DOI: 10.2174/2211555204 666151014224015, 2015
2014 Hsieh YJ, Hwu L, Chen YC, Ke CC, Chen FD, Wang HE, Lin KP, Yeh HH, Chang CW, Liu RS.. 21-Driven Multifusion Gene System for Evaluating the Efficacy of Histone Deacetylase Inhibitors by In Vivo Molecular Imaging and for Transcription Targeting Therapy of Cancer Mediated by Histone Deacetylase Inhibitor. J Nucl Med. 2014 Mar 17. [Epub ahead of print]. (SCI) (Impact factor: 7.022, Ranking: 0.9%), 2014
2014 Ya-Ju Hsieh, Luen Hwu, Chien-Chih Ke, Skye Hsin-Hsien Yeh, Chien-Feng Lin, Fu-Du Chen, Hsin-Ell Wang, Kang-Ping Lin, Ran-Chou Chen and R. Liu. Rational Design of a Triple Reporter Gene for Multimodality Molecular Imaging. Biomed Res Int. 2014;2014:605358. doi: 10.1155/2014/605358. Epub 2014 Apr 7. (Impact factor: 2.880; Rank: 50/159, 31.04%), 2014
2014 Skye Hsin-Hsien Yeh, Ming-Hsien Lin, Fan-Lin Kong, Chi-Wei Chang, Li-Chung Hwang, Chien-Feng Lin, Jeng-Jong Hwang, Ren-Shyan Liu. Evaluation of inhibitory effect of recreational drugs on dopaminergic terminal neuron by PET and whole-body autoradiography. Biomed Res Int. 2014;2014:157923. http://dx.doi.org/10.1155/2014/157923 (Impact factor: 2.880; Rank: 50/159, 31.04%), 2014
2014 Whitehouse A, Doherty K, Yeh HH, Robinson AC, Rollinson S, Pickering-Brown S, Snowden J, Thompson JC, Davidson YS, Mann DM.Histone deacetylases (HDACs) in Frontotemporal Lobar Degeneration. Neuropathol Appl Neurobiol 2014 May 27. doi: 10.1111/nan.12153. [Epub ahead of print] (Impact factor: 4.873; Rank:45/255, 17.85%), 2014
2013 Flores LG 2nd, Yeh HH, Soghomonyan S, Young D, Bankson J, Hu Q, Alauddin M, Huff V, Gelovani JG. Monitoring Therapy with MEK Inhibitor U0126 in a Novel Wilms Tumor Model in Wt1 Knockout Igf2 Transgenic Mice Using [18F]-FDG PET with Dual-Contrast Enhanced CT and MRI: Early Metabolic Response Without Inhibition of Tumor Growth. Mol Imaging Biol. 2013 Apr;15(2):175-85. doi: 10.1007/s11307-012-0588-5. (SCI) (Impact factor: 3.844, Ranking: 12.1%), 2013
2013 Hsin-Hsien Yeh, Rainer Hinz, Suren Soghomonyan, Julius A. Balatoni, Uday Mukhopadhyay, Leo G. Flores, Asutosh Pal, Daniel Young, Hwan Jeong, Rajesh Uthamanthil, James Jackson, William Tong, Mei Tian, Mian M. Alauddin, Karl Herholz, Juri G. Gelovani. Quantification of HDAC activity in the forebrain, N.accumbens, and cerebellum in non-human primates using [18F]FAHA PET/CT and an optimized pharmacokinetic model. Neuroimage. 2013 Jan 1;64:630-9. doi: 10.1016/j.neuroimage.2012.09.019. Epub 2012 Sep 17. (SCI) (Impact factor: 6.252, Ranking: 3/116, 2.6%), 2013
2013 Hsin-Hsien Yeh, Daniel Young, Juri Gelovani Karl Herholz, David Mann. Histone deacetylase (HDAC) class II immunohistochemistry in human brains with Huntington’s disease. Brain Res. 2013 Apr 4;1504:16-24. doi: 10.1016/j.brainres. 2013.02.012. Epub 2013 Feb 16. (SCI) (Impact factor: 2.892; Rank: 126/251, 50.02%), 2013
2013 Skye Hsin-Hsien Yeh, Chien-Feng Lin, Fan-Lin Kong,Hsin-Ell Wang, Ya-Ju Hsieh, Juri G. Gelovani, Ren-Shyan Liu, Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [124I]-Morpholino-IPQA BioMed Research International, 2013.doi:10.1155/2013/549359. (SCI) (Impact factor: 2.880; Rank: 50/159, 31.04%), 2013
2012 Nashaat Turkman, Aleksander Shavrin, Vincenzo Paolillo, Hsin Hsien Yeh, Leo Flores, Suren Soghomonian, Brian Rabinovich, Andrei Volgin, Juri Gelovani, Mian Alauddin Synthesis and preliminary evaluation of [(18)F]-labeled 2-oxoquinoline derivatives for PET imaging of cannabinoid CB(2) receptor. Nucl Med Biol 2012, 39(4):593-600. (SCI) (Impact factor: 2.62, Ranking: 29.4%), 2012
2011 Yeh HH, Ogawa K, Balatoni J, Mukhapadhyay U, Pal A, Gonzalez-Lepera C, Shavrin A, Soghomonyan S, Flores L, Young D, Volgin AY, Najjar AM, Krasnykh V, Tong W, Alauddin MM, Gelovani JG. Molecular Imaging of Active Mutant L858R EGFR Kinase Expressing Non Small Cell Lung Carcinomas using PET/CT with [18F]F-PEG6-IPQA. 2011 Proc Natl Acad Sci USA, 108(4):1603-8. Epub 2011 Jan 10. (SCI) (Impact factor: 9.771, Ranking: 5.1%), 2011
2011 Paolillo V, Yeh H H, Mukhopadhyay U, Gelovani JG, Alauddin MM. Improved detection and measurement of low levels of [18F]fluoride metabolized from [18F]-labeled pyrimidine nucleoside analogues in biological samples. 2011 Nucl Med Biol. Nov;38(8):1129-34. (SCI) (Impact factor: 2.62, Ranking: 29.4%), 2011
2010 Ying Y, Ghosh P, Guo L, Pal A, Mukhapadhyay U, Peng Z, Yeh HH, Bertolini S, Flores LG, Young D, Volgin A, Soghomonyan S, Bornmann W, Logsdon C, Alauddin MM, Gelovani JG. Synthesis and Ex Vivo Autoradiographic Evaluation of Ethyl-beta-D:-galactopyranosyl-(1,4')-2'-deoxy-2'-[(18)F]fluoro-beta-D:-gluco- pyranoside A Novel Radioligand for Lactose-Binding Protein: Implications for Early Detection of Pancreatic Carcinomas with PET. 2010 Mol Imaging Biol Jun;13(3):536-46. (SCI) (Impact factor: 3.844, Ranking: 12.1%), 2010
2010 Schwartz DL, Bankson J, Nishii R, Bidaut L, Yeh HH, He Y, Williams R, Volgin A, Lemos R, Titai-Kumar A, Oh J, Soghomonyan S, Mukhopadhyay, Allaudin M, Mushkudiani I, Kuno N, Krishnan S, Bornmann W, Lai SY, Powis G, Hazle J, Gelovani JG. HIF-1 dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance. 2010 Mol Cancer Res 2011 Mar;9(3):259-70. (SCI) (Impact factor: 2.620, Ranking: 23.0%), 2010
2009 Leo Garcia Flores, Susanna Bertolini, Hsin Hsin Yeh, Danel Young, Uday Mukhapadhyay, Ashutosh Pal, Yunming Ying, Andrei Volgin, Aleksandr Shavrin, Suren Soghomonyan,William Tong, William Bornmann, Mian M. Alauddin, Craig Logsdon, and Juri G. Gelovani. Detection of pancreatic carcinomas by imaging lactose-binding protein expression in peritumoral pancreas using [18F]fluoroethyl-deoxylactose PET/CT. 2009 PLoS One 4(11):e7977. (SCI) (Impact factor: 4.411, Ranking: 13.9%), 2009
2008 Uday Mukhopadhyay, Suren Soghomonyan, Hsin Hsien Yeh, Leo G. Flores, Aleksandr Shavrin, Andrei Y. Volgin, Juri G. Gelovani, Mian M. Alauddin. N3-Substituted thymidine analogues: V. Synthesis and preliminary PET imaging of N3-[18F]fluoroethyl thymidine and 5 N3-[18F]fluoropropyl thymidine. 2008 Nucl Med Biol 35(6):697-705. (SCI) (Impact factor: 2.62, Ranking: 29.4%), 2008
2004 Ye XX, JC Chen, Liu RS, Wey SP, Lee JS, Ting G, Hwang JJ. Microautoraduography of [123I]ADAM in Mice Treated with Fluoxetine and Serotonin Reuptake Inhibitors. 2004 Nucl Med Bio. 31, 557-562. (SCI) (Impact factor: 2.62, Ranking: 29.4%), 2004
2004 Ye XX, Hwang JJ, Shieh JF, JC Chen, YT Chou, KY Tu, Wey SP, Ting G. In Vivo Quantification of bound [123I]ADAM to Serotonin Transporters in the Brains of Rabbits by SPECT. 2004 Nucl Med Biol. 31(8):995-1003. (SCI) (Impact factor: 2.62, Ranking: 29.4%), 2004
2004 Lin KJ, Yen TC, Wey SP, Hwang JJ, Ye XX, KY, Ting, Chen JC. Characterization of the binding sites of [123I]ADAM and the relationship to serotonin transporter in rat and mouse brains using quantitative autoradiography. 2004 J Nucl Med. 45, 673-681. (SCI) (Impact factor: 7.022, Ranking: 0.9%), 2004
2002 Lin KJ, Ye XX, Yen TC, Wey SP, Tzen KY, Ting G, Hwang JJ. Biodistribution study of [123I]ADAM in mice: correlation with whole body autoradiography. 2002 Nucl Med Biol. 29, 643-650. (SCI) (Impact factor: 2.62, Ranking: 29.4%), 2002
年度 論文名稱
2022 Skye Hsin-Hsien Yeh, Chuang-Hsin Chiu, Yu-Yeh Kuo, Chi-Jung Tsai, Tsung-Hsun Yu, Wen-Sheng Huang, Kuo-Hsing Ma⁎. Amitriptyline Accelerates SERT Binding Recovery Rate in MDMA-Induced Rat Model: in vivo 4-[18F]-ADAM PET Imaging. 2022 第37屆生物醫學聯合學術年會-台灣分子醫學影像學會., 2022
2022 Skye Hsin-Hsien Yeh, Yu-Yeh Kuo, Wen-Sheng Huang, Chuang-Hsin Chiu, Tsung-Hsun Yu, Leo Garcia Flores II, Chi-Jung Tsai, Kuo-Hsing Ma⁎. Amitriptyline Accelerates SERT Binding Recovery Rate in MDMA-Induced Rat Model: in vivo 4-[18F]-ADAM PET Imaging. 第37屆生物醫學聯合學術年會-台灣分子醫學影像學會., 2022
2020 Chi-Wei Chang, Chuang-Hsin Chiu, Ming Hsien Lin, Ya-Yao Huang, Chyng-Yann Shiue, Wen-Sheng Huang, Skye Hsin-Hsien Yeh*. Automated radiosynthesis of [18F]FEPPA for PET/MRI brain region-specific imaging of TSPO in vivo. 2020中華民國核醫學年會暨國際學術研討會, Tainan, Taiwan., 2020
2020 S. H. Yeh, W. Huang, C. Chiu, C.T. Chen, K.H. Ma,H.Tian, T. Yu, P. Wang, Y. Kuo, C. Chang. Radiosynthesis and initial evaluation of [18F]FBAT for in vivoPET imaging of inducible nitric oxide synthase. 2020 European Association of Nuclear Medicine, Vienna, Austria., 2020
2019 Chin-Wei Chang, Wen-Sheng Huang, Chuang-Shin Chiu, Haibin Tian, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Skye Hsin-Hsien Yeh*. Imaging dynamic activity of inducible nitric oxide synthase (iNOS) in neuroinflammation with [18F]FBAT PET. 2019中華民國核醫學年會暨國際學術研討會, Tainan, Taiwan., 2019
2019 L. Chao, H.J. Tsay, Skye H.H. Yeh*. Enhancing blood circulation to facilitate the efflux of amyloid β from the brain to peripheral blood circulation by xuefu zhuyu decoction. 2019 Neuroscience, Chicago, USA, 2019
2018 Skye Hsin-Hsien Yeh*, Yi-Heng Lee, Hao-Cheih Hsu, Young-Ji Shiao, Feng-Shiun Shie, Pei-Chen Kao, Shu-Meng Hsu, Chih-Wen Yeh, Shi-Bing Yang, Huey-Jen Tsay. High-Fat Diet Impaired Energy Homeostasis in APPswe/PS1dE9 mice. (Oral presentation) 2018 Asian Nuclear Medicine Academic Forum, Melbourne Australia., 2018
2017 Hsin-Hsien Yeh, Chien-Hung Lin, Fong-Lee Huang, Huey-Jen Tsay, Wen-Sheng Huang. Neuroimaging of inflammation: high fat-induced exacerbation of Alzheimer’s disease. (Oral presentation) 2017 Society of Nuclear Medicine and Molecular Imaging (SNMMI), Denver, USA., 2017
2013 Yu-Ning Tang, Skye Hsin-Hsien Yeh, Jin-Cai Chen, Chin-Wei Cheng, Hsin-Ell Wang, Irene Han-Juo Cheng, Ren-Shyan Liu. Longitudinal coupled-imaging Alzheimer's disease mouse model using [11C]PIB and [18F]FDG PET. (Poster presentation) 2013 Society of Nuclear Medicine and Molecular Imaging, Vancouver, BC, Canada., 2013
2013 Skye Hsin-Hsien Yeh, Jin-Cai Chen, Zuo-Hao Tang, Hui-Jing Lin, Cheng-Ta Li3, Ta-Kai Chou, Wen-Sheng Huang, Dong-Ping Su, Ren-Shyan Liu. PET/CT with [18F]ADAM using a biomarker for quantification of SERT change in the brain of PTSD rat model. (Poster presentation) 2013 Society of Nuclear Medicine and Molecular Imaging, Vancouver, BC, Canada., 2013
2013 Yu-Ning Tang, Skye Hsin-Hsien Yeh, Jin-Cai Chen, Chin-Wei Cheng, Hsin-Ell Wang, Irene Han-Juo Cheng, Ren-Shyan Liu. Longitudinal coupled-imaging Alzheimer's disease mouse model using [11C]PIB and [18F]FDG PET.(Poster presentation) 2013 World Molecular Imaging Congress, Savannah, Georgia., 2013
2013 Skye Hsin-Hsien Yeh, Jin-Cai Chen, Zuo-Hao Tang, Hui-Jing Lin, Cheng-Ta Li3, Ta-Kai Chou, Wen-Sheng Huang, Dong-Ping Su, Ren-Shyan Liu. PET/CT with [18F]ADAM using a biomarker for quantification of SERT change in the brain of PTSD rat model. (Oral presentation) 2013 World Molecular Imaging Congress, Savannah, Georgia., 2013
2012 HsinHsienYeh, Leo G. Flores II, Suren Soghomonyan, Kuneek Kil,VincenzoPaolillo,Uday Mukhopadhyay, Julius Balatoni, AsutoshPal, Aleksandr Shavrin, DanielYoung, Mian Alauddin,William Tong, JuriG. Gelovani. Quantification of Suberoylanilide Hydroxamic and Valproic Acid-Induced Inhibition of HDAC Activity in Rat Brain using In Vivo PET/CT Imaging with HDAC Class IIa-Specific Radiotracers. (Poster presentation) 2012 World Molecular Imaging Congress, San Diego USA., 2012
2012 Hsin-hsien Yeh, Leo G. Flores, Daniel Young, Patrick J. Gillespie, Uday Mukhopadhyay, Asutosh Pal, Hwan Jeong, Nobuyoshi Fukumitsu, William Tong, Mian M Alauddin, Juri G. Gelovani. PET Imaging of Epigentic Mediated by HDACs in a Transgenic Mouse Model of Huntington’s Disease (Poster presentation) 2012 World Molecular Imaging Congress, Dublin, Ireland., 2012
2012 HsinHsienYeh, LeoG.Flores II, Suren Soghomonyan, Kuneek Kil,Vincenzo Paolillo, Uday Mukhopadhyay, Julius Balatoni, Asutosh Pal,Aleksandr Shavrin, Daniel Young, Mian Alauddin, William Tong, Juri G. Gelovani. Quantification of Suberoylanilide Hydroxamic and Valproic Acid-Induced Inhibition of HDAC Activity in Rat Brain using In Vivo PET/CT Imaging with HDAC Class IIa-Specific Radiotracers. (Oral presentation) 2012 World Molecular Imaging Congress, Dublin, Ireland., 2012
2012 Hsin-Hsien Yeh, Mei Tian, Leo G. Flores, Daniel Young, Vincenzo Paolillo, Kun-eek Kil, Uday Mukhopadhyay, Julius A. Balatoni, Suren Soghomonyan, Asutosh Pal, Rajesh Uthamanthil, James Jackson, WilliamTong, Daniel Young, Mian M Alauddin, Juri G. Gelovani. PET/CT/MRI with [18F]TFAHA using an optimized pharmacokinetic model for Quantification of HDAC class II expression –activity in the brain in non-human primates (Oral presentation) 2012 World Molecular Imaging Congress, Dublin, Ireland., 2012
2011 Hsin-Hsien Yeh, Leo G. Flores II, Kun-eek Kil, Vincenzo Paolillo, Uday Mukhopadhyay, Julius Balatoni, Suren Soghomonyan, Aleksander Shavrin, Daniel Young, Mian Alauddin, William Tong, Juri G. Gelovani. Imaging epigenetic regulation in the rat brain mediated by HDACs class IIa Enzymes using PET/CT with 18F-TFAHA and 18F-DFAHA (Poster presentation) 2011 World Molecular Imaging Congress, San Diego USA., 2011
2011 Hsin-hsien Yeh, Leo G. Flores, Daniel Young, Patrick J. Gillespie, Uday Mukhopadhyay, Asutosh Pal, Hwan Jeong, Nobuyoshi Fukumitsu, William Tong, Mian M Alauddin, Juri G. Gelovani. PET Imaging of Epigentic Mediated by HDACs in a Transgenic Mouse Model of Huntington’s Disease (Oral presentation) 2011 World Molecular Imaging Congress, San Diego USA., 2011
2011 Hsin-Hsien Yeh, Mei Tian, Leo G. Flores, Daniel Young, Vincenzo Paolillo, Kun-eek Kil, Uday Mukhopadhyay, Julius A. Balatoni, Suren Soghomonyan, Asutosh Pal, Rajesh Uthamanthil, James Jackson, WilliamTong, Daniel Young, Mian M Alauddin, Juri G. Gelovani. PET/CT/MRI with [18F]TFAHA using an optimized pharmacokinetic model for Quantification of HDAC class II expression –activity in the brain in non-human primates (Oral presentation) 2011 World Molecular Imaging Congress, San Diego USA., 2011
2010 JJ Jong, HH Yeh et, al., Multi-Tracer Molecular-Genetic Imaging Reveals Distinct Areas of Coupling and Uncoupling of Blood Flow and HIF1 Signaling in a Rat Brain Glioma Model. (Poster presentation) 2010 World Molecular Imaging Congress, Kyoto Japan., 2010
2010 Leo Garcia Flores, HsinHsien Yeh et. al., A Novel Model of Renal Tumor in Transgenic Mice: Characterization with Repetitive 18FDG PET and Dual Contrast-Enhanced CT Imaging. (Poster presentation) 2010 World Molecular Imaging Congress, Kyoto Japan., 2010
2010 N. Fukumitsu, H. Yeh, L.G. Flores, S. Soghomonyan, U. Mukhopadhyay, D. Young, M.M. Alauddin, W. Tong, J.G. Gelovani. The Role of HDAC Activation in Chemotherapy-Induced Neurotoxicity and Protective Effects of HDAC Inhibitors in Rats Demonstrated using PET/CT with 18 F-FAHA and 18F-FDG (Oral presentation) 2010 World Molecular Imaging Congress, Kyoto Japan., 2010
2010 Hsin-Hsien Yeh, Rainer Hinz, Suren Soghomonyan, Julius A. Balatoni, Uday Mukhopadhyay, Leo G. Flores, Asutosh Pal, Hwan Jeong, Rajesh Uthamanthil, James Jackson, William Tong, Mei Tian, Mian M. Alauddin, Karl Herholz, Juri G. Gelovani. Quantification of HDAC activity in the forebrain, N.accumbens, and cerebellum in non-human primates using [18F]FAHA PET/CT and an optimized pharmacokinetic model. (Oral presentation) 2010 World Molecular Imaging Congress, Kyoto Japan., 2010
2008 Hsin Hsien Yeh, Kazuma Ogawa, Julius Balatoni, Uday Mukhapadhyay, Asutosh Pal, Daniel Yang, Andrei Volgin, Mian Alauddin, Juri G. Gelovani. Imaging the Expression-Activity and Mutational Status of EGFR in Four Different Non Small Cell Carcinoma Xenografts in Mice using PET with [18F]F-PEG6-IPQA. . (oral presentation) 2008 World Molecular Imaging Congress, France Nice., 2008
2008 Hsin Hsien Yeh, Asutosh Pal, Julius Balatoni, Kazuma Ogawa, Leo Flores, Andrei Volgin, Daniel Yang, Juri G. Gelovani.Imaging Expression-Activity and Mutational Status of EGFR in Intracerebral Glioma Xenografts in Mice with [124I]I-PEG6-IPQA and PET. 2008 World Molecular Imaging Congress, France Nice., 2008
2008 Hsin Hsien Yeh, Ryuichi Nishii, Julius Balatoni, Asutosh Pal, Suren Soghomonyan, Leo Flores1, Andrei Volgin, Daniel Yang, Juri G. Gelovani. (2008) PET with [124I]I-PEG6-IPQA for Imaging Expression-Activity and Mutational Status of EGFR in Four Different Non Small Cell Carcinoma Xenografts in Mice. 2008 World Molecular Imaging Congress, France Nice., 2008
2008 HsinHsien Yeh, Suren Soghomonyan, Uday Mukhapadhayay, Daniel Young, Leo G. Flores,Asutosh Pal, Kazuma Ogawa, Raymond Gibson, Mian Alauddin, William Tong, Juri G. Gelovani. Quantification of Valporic Acid-induced Dose-Dependent Inhibition of HDACs Activity in the Rat Brain using In Vivo PET Imaging with 18FAHA. 2008 World Molecular Imaging Congress, France Nice., 2008
2008 Hsin-Hsien Yeh, Suren Soghomonyan, Uday Mukhapadhyay, Daniel Young, Leo G. Flores, Asutosh Pal, Kazuma Ogawa, Raymond Gibson, Thomas Miller, Mian Alauddin, William Tong, Juri G.Gelovani. Determination of Dose-Dependent Inhibition of HDACs Activity induced by para-Fluoro-SAHA in the Rat Brain using In Vivo PET Imaging with [18F]FAHA. 2008 World Molecular Imaging Congress, France Nice., 2008
2008 Hsin-Hsien Yeh, Daniel Young, Raymond Gibson, William Tong, Juri G. Gelovani. (2008) Imaging Expression-Activity of HDACs in the Awake Rat Brain using Autoradiography with [14C]AHA as a Prototype for [11C]AHA and PET. 2008 World Molecular Imaging Congress, France Nice., 2008
2008 Hsin Hsien Yeh, Suren Soghomonyan, Uday Mukhapadhya, Daniel Young, Leo G. Flores, Asutosh Pal, Kazuma Ogawa, Mian Alauddin, Raymond Gibson, Willian Tong, Juri G. Gelovani. Assessment of SAHA-induced Dose-Dependent Inhibition of HDACs Activity in the Rat Brain using In Vivo PET Imaging with 18FAHA. (Oral presentation) 2008 World Molecular Imaging Congress, France Nice., 2008
2007 Ryuichi Nishii, Uday Mukhopadhyay, Hsin Yeh, Suren Soghomonyan, Andrei Volgin, Mian Alauddin, William Tong, Juri Gelovani. 2007 Non-invasive imaging of histone deacetylase activity in human breast carcinoma xenografts in rats using positron emission tomography (PET) with [18F]-FAHA. 2007 Joint Molecular Imaging Conference, Providence, Rhode Island, USA, 2007
2007 Ryuichi Nishii, Uday Mukhopadhyay, Hsin Yeh, Suren Soghomonyan, Andrei Volgin, Mian Alauddin, William Tong, Juri Gelovani. PET imaging of histone deacetylase activity in a rat brain using 6-([18F]-fluoroacetamide)-1-hexanoicanilide ([18F]-FAHA). 2007 Joint Molecular Imaging Conference, Providence, Rhode Island, USA, 2007
2007 U. Mukhopadhyay, S. Soghomonyan, A. Y. Volgin, H. H. Yeh, L. G Flores, J. G. Gelovani and M. M. Alauddin. Synthesis and preliminary PET imaging of N3-[18F]fluoroethyl thymidine and N3-[18F]fluoropropyl thymidine. 2007 Joint Molecular Imaging Conference, Providence, Rhode Island, USA., 2007
2006 Ryuchi Nishii, Asutosh Pal, Suren Soghomonyan, Julius Balatoni, Ioseb Mushkudiani, Hsin Hsien Yeh, Uday Mukhopadhyay, Andrei Volgin, Aleksander Shavrin, David Maxwell, William Tong, Mian Alauddin, William Bornmann, Juri Gelovani Molecular Imaging of Different EGFR Kinase Mutant NSCL Carcinomas with [124I]-Mipqa PET for Prediction of Responsiveness to EGFR Kinase Inhib. 2006 Joint Molecular Imaging Conference, Hilton Waikoloa Village on the Big Island of Hawaii ., 2006
2006 David Schwartz, Sunil Krishnan, Norihito Kuno, Ioseb Mushkudiani, Andrei Volgin, Hsin Hsien Yeh, Yi He, Suren Soghomonyan, Uday Mukhopadhyay, Mian Alauddin, Shujun Shentu, Garth Powis, Juri Gelovani Molecular-Genetic In Vitro and In Vivo Imaging of HIF-1 Signaling Response to Radiation and Targeted Inhibition. 2006 Joint Molecular Imaging Conference, Hilton Waikoloa Village on the Big Island of Hawaii, 2006
2003 Ye XX, Hwang JJ, Chen JC, Shieh JF, YT Chou. SPECT Imaging of Serotonin Transporters in the Brains of Rabbits by [123I]ADAM. 2003 Annual Meeting of the Society of Nuclear Medicine, New Orleans, USA., 2003
2002 Lin KJ, Ye XX, Yen TC, et al. Biodistribution study of [123I]ADAM in mice: correlation to whole body autoradiography. 2002 Annual Meeting of the Society of Nuclear Medicine, Los Angeles, USA., 2002
2002 Ye XX, Hwang JJ, Hsieh JF, Chen JC. In Vivo quantification of bound [123I]ADAM in serotonin transporters in the brains of rabbits by SPECT. (oral presentation) 2002 Annual Meeting of the Society of Nuclear Medicine, Los Angles, USA., 2002
2001 Lin KJ, Yen TC, Ye XX, et al. The biodistribution of I-123 ADAM in mouse with macroautoradiography. 2001 Annual Meeting of the Society of Nuclear Medicine, Taipei, Taiwan., 2001
2001 Ye XX, Hwang JJ, Chen JC, Shieh JF. In Vivo quantification of bound 123I-ADAM in serotonin transporters in rabbit by SPECT. 2001 Annual Meeting of the Society of Nuclear Medicine, Taipei, Taiwan., 2001
年度 書名
2017 Yeh SH*, Kong F-L, Lin M-H. Book chapter “Visualization of Apoptosis: Annexin V imaging. In: Inoue T, Huang G, Yang DJ (eds), Personalized Pathway-Activated Systems Imaging in Oncology (Principle and Instrument)”, Springer-Verlag, Japan, 2017 ISBN: 978-981-10-3348-3., 2017
2016 Skye HH Yeh, Fang CK, Hwang JJ* (2016):Book chapter “Effects of Club Drugs on Dopaminergic and Serotonergic Systems and Diagnosis with [18F]FDOPA, [99mTc]TRODAT-1 and [I*]ADAM”, pp391－405, Part II, Club Drugs in Neuropathology of Drug addictions and Substance Misuse", Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants, and International Aspects. Edited by Victor R. Preedy. Academic Press, Elsevier Publishing Inc. ISBN: 978-0-12-800212-4., 2016
獎項名稱 年度 記事
Travel Award 2013
Overseas Research Students Award 2012
Selected Abstracts for Highlight Lecture 2012 • PET/CT/MRI with [18F]TFAHA using an optimized pharmacokinetic model for quantification of HDAC class II expression-activity in the brain of non-human primates.
• PET/CT/MRI with [18F]TFAHA using an optimized pharmacokinetic model for quantification of HDAC class II expression-activity in the brain of non-human primates.
Overseas Research Students Award 2011
Student Travel Award 2011
Performance Award 2011
Overseas Research Students Award 2010
Student Travel Award 2010
Overseas Research Students Award 2009
Performance Award 2009
Graduate Scholarship 2008
Student Travel Award 2008
Performance Award 2008
Graduate Scholarship 2007
Graduate Scholarship 2006
Graduate Scholarship 2005
The Best Annual Investigation 2001 Title：Biodistribution Study of [123I] ADAM in Mice: correlate to whole body autoradiography